Paths not taken: Notch signaling pathway keeps immature T cells on the right track

One protein called Notch, which has well-known roles in the development of multiple tissues, plays an essential role in triggering T-cell development. Notch signaling induces expression of genes that promote the maturation of T cells and discourage alternative cell fates. Deficiency of the Notch target gene Hes1 in blood stem cells results in extremely low T-cell numbers, and could shed light on how normal cells are transformed in the context of cancer.

Fuente : http://www.eurekalert.org/pub_releases/2013-11/uop…