EGF receptor ecto-domain mutations: When to screen and when not to screen

The epidermal growth factor receptor (EGFR) is expressed in normal colonic cells and is activated by specific peptide growth factors that regulate cell proliferation, survival and differentiation. Increased expression and activation of the EGFR has been observed in the majority of colorectal carcinoma, suggesting that the EGFR pathway plays an important role in colon carcinogenesis.

Fuente : http://www.eurekalert.org/pub_releases/2013-12/lb-…



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