RI Hospital: Absence of specific enzyme in cartilage can lead to benign tumors in mice

Rhode Island Hospital researchers have found that the absence of the Shp-2 enzyme near specialized cartilage cells can lead to the development of multiple benign cartilage tumors in mice, a model that recapitulates the rare human tumor syndrome metachondromatosis. Shp2 is an enzyme in the cell that regulates the activity of other proteins and signaling pathways. Mice lacking Shp2 formed two types of tumors: enchondromas and osteochondromas, and also developed deformed joints.

Fuente : http://www.eurekalert.org/pub_releases/2013-07/l-r…



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